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The innards and bottom end of the Boss motor should be able to take a fair amount of additional push. The question is just how much? Properly intercooled, I would think a reasonable amount of boost would be doable without sacrificing durability IMO.
The R/&D on this twin turbo kit is still on going, with an appearance at the Texas Mile at the end of this month. The kit is in a stock automatic car right now but will be tested in a street stick car next. Eventually it will be installed in a Boss 302 track car. The results at Bradenton was with 18-20# of boost. As for R/R ,as little as 4-6 # should provide good results.